PTX3 molecular target information overview
Overview of PTX3 molecular targets
Pentraxin3, also known as tumor necrosis factor-induced gene 14 (TSG-14), is a member of the pentraxin superfamily and has a ring-shaped multimeric structure. Various types of cells, especially mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells, can rapidly produce and release pentraxin3 in response to primary inflammatory signals (such as toll-like receptors, TNF-α, IL-1β). Pentraxin3 is an acute phase response protein. Its content is low under normal conditions (about 25ng/ml in mice and less than 2ng/ml in humans), but it rises sharply (peaking 6-8 hours after induction) in endotoxic shock, sepsis and other inflammatory and infectious conditions, and the content can reach 200-800ng/ml, which is related to the severity of the disease. In these cases, pentraxin3 is a rapid marker for local activation of innate immunity and inflammatory response. Studies have shown that pentraxin3 has a dual role: protecting the body against pathogens and regulating autoimmunity.
Human PTX3 Molecular Target Information
Molecular name: PTX3, pentraxin 3
Alias:
- long pentraxin 3
- pentaxin-related gene, rapidly induced by il-1 beta
- pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5
- pentaxin-related protein PTX3
- pentaxin 3, long
- pentraxin-3
- pentraxin-related gene, rapidly induced by IL-1 beta
- pentraxin-related protein PTX3
- TNF alpha-induced protein 5
- TNFAIP5
- TSG-14
- tumor necrosis factor alpha-induced protein 5
- tumor necrosis factor-inducible gene 14 protein
- tumor necrosis factor-inducible protein TSG-14
- tumor necrosis factor, alpha-induced protein 5
Gene sequence:NCBI_Gene: 5806
Protein sequence:UniProtKB: P26022
Human PTX3 target molecular function (prediction)
Enables complement component C1q complex binding activity; identical protein binding activity; and virion binding activity. Involved in innate immune response; modulation by host of viral process; and negative regulation of viral entry into host cell. Located in extracellular space. Implicated in cystic fibrosis and invasive aspergillosis. Biomarker of hepatitis C; invasive aspergillosis; pelvic inflammatory disease; pulmonary aspergilloma; and toxic shock syndrome.
Mouse Ptx3 molecular target information
Molecular name: Ptx3, pentraxin related gene
Alias:
- AI607804
- expressed sequence AI607804
- pentraxin 3
- TSG-14
Gene sequence:NCBI_Gene: 19288
Protein sequence:
Mouse Ptx3 target molecular function (prediction)
Enables (1->3)-beta-D-glucan binding activity. Acts upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Located in extracellular matrix. Is expressed in cochlea; cochlea epithelium; inner ear vestibular component; organ of Corti; and stria vascularis. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3).
Rat Ptx3 molecular target information
Molecular name: Ptx3, pentraxin 3
Alias:
- LOC689388
- pentraxin 3, long
- pentraxin related
- pentraxin related gene
- pentraxin-related protein PTX3
- similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)
Gene sequence:NCBI_Gene: 689388
Protein sequence:UniProtKB: D3ZT94
Rat Ptx3 target molecular function (prediction)
Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; complement component C1q complex binding activity; and virion binding activity. Predicted to be involved in innate immune response; modulation by host of viral process; and negative regulation of viral entry into host cell. Predicted to act upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3).