VEGFC molecular target information overview
Review of VEGFC molecular targets
Vascular endothelial growth factor C (VEGF-C) is a dimeric secretory protein and a member of the PDGF/VEGF family. Translated VEGF-C has three domains: the middle VEGF homology domain (VHD), the N-terminal domain (propeptide), and the C-terminal domain (propeptide). VEGF-C plays an important role in the formation of lymphatic vessels, mainly by binding to its receptor VEGFR-3 to act on lymphatic endothelial cells, thereby promoting their survival, growth and migration. Studies have shown that VEGF-C is a specific growth factor for various model lymphatic vessels. In addition to its effects on lymphatic vessels, VEGF-C can also promote the growth of blood vessels and regulate vascular permeability by binding to its main receptor VEGFR-3 or secondary receptor VEGFR-2. In addition, VEGF-C also plays an important role in neural development and blood pressure regulation. Lack of VEGF-C can lead to lymphedema, while excess VEGF-C is associated with tumor angiogenesis and metastasis.
Human VEGFC Molecular Target Information
Molecular name:VEGFC, vascular endothelial growth factor C
Alias:
- FLT4 ligand DHM
- Flt4-L
- LMPH1D
- LMPHM4
- vascular endothelial growth factor-related protein
- VEGF-C
- VRP
Gene sequence:NCBI_Gene: 7424
Protein sequence:UniProtKB: P49767
Human VEGFC target molecular function (prediction)
Enables chemoattractant activity and vascular endothelial growth factor receptor 3 binding activity. Involved in induction of positive chemotaxis; positive regulation of mast cell chemotaxis; and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in extracellular region and platelet alpha granule lumen. Predicted to be active in extracellular space. Implicated in breast carcinoma and hereditary lymphedema ID. Biomarker of several diseases, including invasive ductal carcinoma; liver disease (multiple); papillary carcinoma; pterygium; and urinary system cancer (multiple).
Mouse Vegfc molecular target information
Molecular name:Vegfc, vascular endothelial growth factor C
Alias:
- AW228853
- expressed sequence AW228853
- VEGF-C
Gene sequence:NCBI_Gene: 22341
Protein sequence:
Mouse Vegfc target molecular function (prediction)
Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lymphangiogenesis; and positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).
Rat Vegfc molecular target information
Molecular name:Vegfc, vascular endothelial growth factor C
Alias:
- flt4 ligand
- flt4-L
- vascular endothelial growth factor-related protein
- VEGF-C
- VRP
Gene sequence:NCBI_Gene: 114111
Protein sequence:UniProtKB: O35757
Rat Vegfc target molecular function (prediction)
Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including positive regulation of blood vessel endothelial cell migration; positive regulation of protein autophosphorylation; and of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or regulation within positive regulation of neuroblast proliferation. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of colon adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).