MMP7 molecular target information overview
Overview of MMP7 molecular targets
Matrix metalloproteinase 7 (MMP-7), also known as stromelysin, is encoded by the MMP7 gene in humans. MMP-7 is normally expressed in epithelial cells, liver, and mammary glands. The expression of MMP-7 is regulated by the Wnt/β-catenin signaling pathway and mediated by transforming growth factor β (TGF-β). The main role of cleaved/activated MMP-7 is to break down the extracellular matrix by degrading macromolecules including casein, gelatin types I, II, IV, and V, fibronectin, and proteoglycans. MMP-7 may be involved in tumor metastasis and inflammatory processes. Upregulated MMP-7 is associated with many malignancies including esophageal, gastric, colon, liver, pancreatic, and renal cell carcinomas. MMP-7 is highly expressed in advanced colorectal adenomatous polyps with severe dysplasia, and it is involved in the transformation of colorectal adenomas to a malignant state and promotes their growth.
Human MMP7 molecular target information
Molecular name: MMP7, matrix metallopeptidase 7
Alias:
- matrilysin
- matrin
- matrix metallopeptidase 7 (matrilysin, uterine)
- matrix metalloproteinase 7
- matrix metalloproteinase 7 (matrilysin, uterine)
- matrix metalloproteinase-7
- MMP-7
- MPSL1
- PUMP-1
- pump-1 protease
- uterine matrilysin
- uterine metalloproteinase
Gene sequence:NCBI_Gene: 4316
Protein sequence:UniProtKB: P09237
Human MMP7 target molecular function (prediction)
Enables endopeptidase activity and metallopeptidase activity. Involved in positive regulation of cell migration and proteolysis. Acts upstream of or within membrane protein ectodomain proteolysis and membrane protein intracellular domain proteolysis. Located in extracellular exosome. Biomarker of endometrial cancer; endometrial hyperplasia; glioblastoma; and lung non-small cell carcinoma.
Mouse Mmp7 molecular target information
Molecular name: Mmp7, matrix metallopeptidase 7
Alias:
- MAT
- matrilysin
Gene sequence:NCBI_Gene: 17393
Protein sequence:
Mouse Mmp7 target molecular function (prediction)
Enables peptidase activity. Acts upstream of or within several processes, including defense response to bacterium; proteolysis; and response to xenobiotic stimulus. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; liver and biliary system; and reproductive system. Orthologous to human MMP7 (matrix metallopeptidase 7).
Rat Mmp7 molecular target information
Molecular name: Mmp7, matrix metallopeptidase 7
Alias:
- matrilysin
- matrin
- matrix metalloproteinase 7
- Matrix metalloproteinase 7 (matrilysin)
- matrix metalloproteinase-7
- MMP-7
- MPMM
- pump-1 protease
- uterine metalloproteinase
Gene sequence:NCBI_Gene: 25335
Protein sequence:UniProtKB: P50280
Rat Mmp7 target molecular function (prediction)
Enables heparin binding activity. Involved in several processes, including cellular response to mechanical stimulus; estrous cycle; and maternal process involved in female pregnancy. Located in cell surface and extracellular space. Used to study hypertension and prostate carcinoma. Biomarker of bladder neck obstruction; coronary restenosis; hypertension; prostate cancer; and renal hypertension. Orthologous to human MMP7 (matrix metallopeptidase 7).