CSF1 molecular target information overview
Overview of CSF1 molecular targets
Macrophage colony-stimulating factor (M-CSF) also known as colony-stimulating factor 1 (CSF1) is a cytokine secreted by osteoblasts. It is a hematopoietic growth factor involved in the proliferation, differentiation and survival of monocytes, macrophages and myeloid progenitor cells. M-CSF produced locally in the vessel wall promotes the progression of atherosclerosis. M-CSF plays a role in renal diseases, including acute kidney injury (AKI) and chronic renal failure (CRF). Chronic activation of monocytes leads to multiple metabolic, hematological and immune abnormalities in patients with CRF. In patients with AKI, M-CSF promotes repair but also has the opposite effect, promoting the proliferation of pro-inflammatory macrophages.
Human CSF1 Molecular Target Information
Molecular name: CSF1, colony stimulating factor 1
Alias:
- colony stimulating factor 1 (macrophage)
- CSF-1
- lanimostim
- macrophage colony stimulating factor
- macrophage colony stimulating factor 1
- macrophage colony-stimulating factor 1
- MCSF
- MGC31930
Gene sequence:NCBI_Gene: 1435
Protein sequence:UniProtKB: P09603
Human CSF1 target molecular function (prediction)
Enables cytokine activity; growth factor activity; and protein homodimerization activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of macrophage migration. Acts upstream of or within positive regulation of cell population proliferation. Located in several cellular components, including extracellular space; nuclear body; and perinuclear region of cytoplasm. Implicated in interstitial cystitis. Biomarker of several diseases, including COVID-19; atherosclerosis; end stage renal disease; glomerulonephritis (multiple); and vesicoureteral reflux.
Mouse Csf1 molecular target information
Molecular name: Csf1, colony stimulating factor 1 (macrophage)
Alias:
- C87615
- colony stimulating factor, macrophage
- colony-stimulating factor-1
- CSF-1
- Csfm
- expressed sequence C87615
- M-CSF
- op
- osteopetrosis
Gene sequence:NCBI_Gene: 12977
Protein sequence:
- UniprotKB: P07141
- UniprotKB: D3YTW1
- UniprotKB: D3Z090
- UniprotKB: F6RNW8
- UniprotKB: Q3TDK0
- UniprotKB: Q3TLQ6
- UniprotKB: Q3U4F9
Mouse Csf1 target molecular function (prediction)
Acts upstream of or within several processes, including mammary gland regulation development; osteoclast proliferation; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and hindlimb long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).
Rat Csf1 molecular target information
Molecule name: Csf1, colony stimulating factor 1
Alias:
- colony stimulating factor 1 (macrophage)
- colony stimulating factor 1 (macrophage)
- CSF-1
- macrophage colony-stimulating factor 1
- MCSF
Gene sequence:NCBI_Gene: 78965
Protein sequence:
Rat Csf1 target molecular function (prediction)
Enables identical protein binding activity. Involved in several processes, including myeloid leukocyte differentiation; odontogenesis; and ossification. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; high grade glioma; and osteopetrosis. Biomarker of systemic scleroderma. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).