Overview of APOB molecular target information
Overview of APOB molecular targets
Apo B is the major apolipoprotein in chylomicrons, very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and low density lipoprotein (LDL) particles, responsible for transporting fat molecules (lipids). Apo B can be divided into two subclasses, Apo B48 and Apo B100, due to differences in amino acid composition. High levels of Apo B, especially together with high concentrations of LDL, are the main driving force for vascular disease (atherosclerosis). Excess Apo B in the liver causes lipid-induced endoplasmic reticulum stress and insulin resistance. Studies have shown that the Apo B-100/Apo A1 ratio is more effective in predicting the risk of heart attack in patients with acute myocardial infarction than measuring Apo B-100 or Apo A1 alone.
Human APOB molecular target information
Molecular name: APOB, apolipoprotein B
Alias:
- apo B-100
- apoB-100
- apoB-48
- apolipoprotein B (including Ag(x) antigen)
- apolipoprotein B-100
- apolipoprotein B48
- FCHL2
- FLDB
- LDLCQ4
- mutant Apo B 100
Gene sequence:NCBI_Gene: 338
Protein sequence: UniProtKB: P04114
Human APOB target molecular function (prediction)
Enables several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Involved in several processes, including cholesterol homeostasis; low-density lipoprotein particle clearance; and low-density lipoprotein particle remodeling. Located in cytosol; Implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Biomarker of several diseases, including common bile duct neoplasm; diabetes mellitus (multiple); familial combined hyperlipidemia; hypobetalipoproteinemia; and obesity.
Mouse Apob molecular target information
Molecular name: Apob, apolipoprotein B
Alias:
- AI315052
- apob-100
- apob-48
- expressed sequence AI315052
Gene sequence:NCBI_Gene: 238055
Protein sequence:
Mouse Apob target molecular function (prediction)
Predicted to enable several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Acts upstream of or within several processes, including cholesterol efflux; lipoprotein metabolic process; and triglyceride metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including adrenal gland; brain; extraembryonic component; genitourinary system; and gut. Used to study familial hypobetalipoproteinemia 2. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).
Rat Apob molecular target information
Molecular name: Apob, apolipoprotein B
Alias:
- Aa1064
- Ac1-060
- Apo B-100
- ApoB-100
- ApoB-48
- apolipoprotein B (including Ag(x) antigen)
- apolipoprotein B PI
- apolipoprotein B-100
- apolipoprotein B-48
Gene sequence:NCBI_Gene: 54225
Protein sequence:
- UniprotKB: F1M6Z1
- UniprotKB: Q4G047
- UniprotKB: Q62970
- UniprotKB: Q63051
- UniprotKB: Q63052
- UniprotKB: Q7TMA5
Rat Apob target molecular function (prediction)
Predicted to enable several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to estradiol; and triglyceride catabolic process. Located in several cellular components, including extracellular space; vesicle lumen; lipoprotein particle. Biomarker of fatty liver disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).