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CDH3 Molecular Target Information Overview


  • Molecular name: CDH3, cadherin 3
  • Gene family: Type I classical cadherins
  • Alias: CDHP; PCAD
  • Alias: P-cadherin; cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental)


    • CDH3 molecular target review


    The cadherin superfamily includes many cell surface glycoproteins containing one or more cadherin repeat sequences, which are involved in calcium-dependent cell adhesion. Placental cadherin (P-cadherin) is a calcium-dependent adhesion molecule expressed in the placenta, epidermis and mammary gland. It plays an important role in the morphogenesis, growth and differentiation of tissues and cells, and plays a pivotal role in regulating morphogenesis and maintaining the structural integrity and polarity of adult tissues. In addition, it is also of great significance to the infiltration of tumor cells.


    Human CDH3 Molecular Target Information


    Molecular name: CDH3, cadherin 3


    Alias:

    • cadherin 3, type 1, P-cadherin (placental)
    • cadherin-3
    • calcium-dependent adhesion protein, placental
    • CDHP
    • HJMD
    • PCAD

    Gene sequence:NCBI_Gene: 1001

    Protein sequence:UniProtKB: P22223


    Human CDH3 target molecular function (prediction)


    Predicted to enable cadherin binding activity and calcium ion binding activity. Involved in several processes, including negative regulation of timing of catagen; positive regulation of signal transduction; and regulation of gene expression. Located in cell junction and plasma membrane. Implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome.


    Mouse Cdh3 molecular target information


    Molecular name: Cdh3, cadherin 3


    Alias:

    • AI385538
    • Cadp
    • expressed sequence AI385538
    • P-cadherin
    • Pcad
    • placental cadherin


    Gene sequence:NCBI_Gene: 12560

    Protein sequence:


    Mouse Cdh3 target molecular function (prediction)


    Predicted to enable cadherin binding activity and calcium ion binding activity. Acts upstream of or within cell-cell adhesion. Located in adherens junction and plasma membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3).


    Rat Cdh3 molecular target information


    Molecular name: Cdh3, cadherin 3

    Alias:

    • cadherin 3, type 1, P-cadherin (placental)
    • cadherin-3

    Gene sequence:NCBI_Gene: 116777

    Protein sequence:UniProtKB: F1LMI3


    Rat Cdh3 target molecular function (prediction)


    Predicted to enable cadherin binding activity and calcium ion binding activity. Involved in response to xenobiotic stimulus and wound healing. Located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3).