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ITGA2 molecular target information overview


  • Molecular name: ITGA2, integrin subunit alpha 2
  • Gene family: CD molecules; Integrin alpha subunits
  • Alias: CD49b
  • Previous name: CD49B
  • Alias: alpha 2 subunit of VLA-2 receptor; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)


    • ITGA2 molecular targets review


    CD49b, also known as integrin α2, is a 150 kD membrane surface glycoprotein. CD49b (integrin α2) non-covalently binds to CD29 (integrin β1) to form a heterodimer VLA-2, platelet glycoprotein Ia/IIa (CD49b/CD29), which mediates the adhesion between mature megakaryocytes and platelets and collagen. CD49b is expressed on platelets, intestinal epithelial cells, NK cells, epithelial cells, and activated T cells, and plays an important role in mediating cell adhesion to the extracellular matrix.


    Human ITGA2 Molecular Target Information


    Molecular name: ITGA2, integrin subunit alpha 2


    Also known as:

    • alpha 2 subunit of VLA-2 receptor
    • BDPLT9
    • BR
    • CD49 antigen-like family member B
    • CD49B
    • collagen receptor
    • GPIa
    • HPA-5
    • human platelet alloantigen system 5
    • integrin alpha 2
    • integrin alpha-2
    • integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
    • platelet antigen Br
    • platelet glycoprotein GPIa
    • platelet glycoprotein Ia
    • platelet membrane glycoprotein Ia
    • very late activation protein 2 receptor, alpha-2 subunit
    • VLA-2
    • VLA-2 subunit alpha
    • VLA2 receptor, alpha-2 subunit
    • VLAA2

    Gene sequence:NCBI_Gene: 3673

    Protein sequence:UniProtKB: P17301


    Human ITGA2 target molecular function (prediction)


    Enables collagen binding activity involved in cell-matrix adhesion and collagen receptor activity. Involved in several processes, including cell adhesion mediated by integrin; cell surface receptor signaling pathway; and mesodermal cell differentiation. Located in cell surface; focal adhesion; and plasma membrane. Part of integrin alpha2-beta1 complex. Implicated in several diseases, including Behcet's disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand's disease (multiple). Biomarker of type 2 diabetes mellitus.


    Mouse Itga2 molecular target information


    Molecular name: Itga2, integrin alpha 2


    Alias:

    • CD49B
    • DX5
    • VLA-2 receptor, alpha 2 subunit


    Gene sequence:NCBI_Gene: 16398

    Protein sequence:


    Mouse Itga2 target molecular function (prediction)


    Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Predicted to act upstream of or within cell adhesion. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2).


    Rat Itga2 molecular target information


    Molecular name: Itga2, integrin subunit alpha 2

    Alias:

    • CD49B
    • GPIa
    • HPA-5
    • integrin alpha 2
    • integrin alpha-2
    • integrin, alpha 2
    • platelet glycoprotein Ia

    Gene sequence:NCBI_Gene: 170921

    Protein sequence:UniProtKB: A0A0G2K470


    Rat Itga2 target molecular function (prediction)


    Enables collagen binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including gland development; positive regulation of cell migration; and positive regulation of cellular component organization. Located in several cellular components, including axon terminus; focal adhesion; and perinuclear region of cytoplasm. (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2).