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THBS1 molecular target information overview


  • Molecular name: THBS1, thrombospondin 1
  • Alias: TSP1; THBS; TSP; THBS-1; TSP-1
  • Alias: thrombospondin-1p180


    • Overview of THBS1 molecular targets


    Thrombospondin-1 (THBS-1) is a member of the thrombospondin family and mediates cell-cell and cell-matrix interactions. The protein binds to fibrinogen, fibronectin, laminin, type V collagen, and integrin α-V/β-1. It plays a role in platelet aggregation, angiogenesis, and tumorigenesis. In normal tissues, it is a natural inhibitor of new blood vessel formation and tumorigenesis. THBS-1 also positively and negatively regulates endothelial cell adhesion, motility, and growth. By blocking the binding of THBS-1 to cell surface receptors (CD47), normal tissues are virtually immune to tumor radiation therapy and contribute to tumor death.


    Human THBS1 Molecular Target Information


    Molecular name: THBS1, thrombospondin 1


    Alias:

    • glycoprotein G
    • THBS
    • THBS-1
    • thrombospondin-1
    • thrombospondin-1p180
    • thrombospondin-p50
    • TSP
    • TSP-1
    • TSP1

    Gene sequence:NCBI_Gene: 7057

    Protein sequence:UniProtKB: P07996


    Human THBS1 target molecular function (prediction)


    Acts upstream of or within several processes, including negative regulation of endothelial cell chemotaxis; negative regulation of endothelial cell proliferation; and negative regulation of nitric oxide mediated signal transduction. Located in several cellular components, including external side of plasma membrane; extracellular space; and platelet alpha granule. Part of fibrinogen complex. Colocalizes with collagen-containing extracellular matrix. Implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Biomarker of COVID-19; cholangiocarcinoma; obesity; pancreatic cancer (multiple); and urinary bladder cancer.


    Mouse Thbs1 molecular target information


    Molecular name: Thbs1, thrombospondin 1


    Alias:

    • tbsp1
    • Thbs-1
    • TSP-1
    • TSP1


    Gene sequence:NCBI_Gene: 21825

    Protein sequence:


    Mouse Thbs1 target molecular function (prediction)


    Acts upstream of or within several processes, including cellular response to nitric oxide; circulatory system development; and monocyte aggregation. Located in extracellular space and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1).


    Rat Thbs1 molecular target information


    Molecular name: Thbs1, thrombospondin 1

    Alias:

    • thrombospondin-1
    • TSP-1
    • Tsp1

    Gene sequence:NCBI_Gene: 445442

    Protein sequence:


    Rat Thbs1 target molecular function (prediction)


    Enables transforming growth factor beta binding activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of transforming growth factor beta production; and response to testosterone. Located in cytoplasm and extracellular space. Biomarker of diabetic retinopathy; heart disease; myocardial infarction; and prostate cancer. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1).