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TIMP3 molecular target information overview


  • Molecular name: TIMP3, TIMP metallopeptidase inhibitor 3
  • Gene family: Tissue inhibitor of metallopeptidases
  • Former name: SFD
  • Alias: tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)


    • Overview of TIMP3 molecular targets


    Tissue inhibitor of metalloproteinase 3 (TIMP-3) is a protein encoded by the TIMP3 gene in the human body and belongs to the tissue inhibitor of metalloproteinase gene family. This family has four members: TIMP-1, TIMP-2, TIMP-3 and TIMP-4. TIMP-3 is a glycoprotein with a molecular weight of 30 kDa secreted by many types of cells. TIMP-3 inhibits active MMP-mediated proteolysis by forming a non-covalent binary complex with the MMP active site through its N-terminal domain. In addition, TIMP-3 is also an inhibitor of inflammatory factors, negatively regulating TACE and promoting the release of TNF-α, which in turn causes inflammatory response and vascular remodeling in the body. Mutations in this gene are associated with autosomal dominant Sorsby fundus dystrophy.


    Human TIMP3 molecular target information


    Molecular name: TIMP3, TIMP metallopeptidase inhibitor 3


    Alias:

    • HSMRK222
    • K222
    • K222TA2
    • metalloproteinase inhibitor 3
    • MIG-5 protein
    • protein MIG-5
    • SFD
    • TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    • TIMP-3
    • tissue inhibitor of metalloproteinase 3
    • tissue inhibitor of metalloproteinases 3

    Gene sequence:NCBI_Gene: 7078

    Protein sequence:UniProtKB: P35625


    Human TIMP3 target molecular function (prediction)


    Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of TRAIL-activated apoptotic signaling pathway. Located in nucleus. Colocalizes with collagen-containing extracellular matrix. Implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Biomarker of several diseases, including breast cancer (multiple); preretinal fibrosis; reproductive organ cancer (multiple); thoracic aortic aneurysm; and type 2 diabetes mellitus.


    Mouse Timp3 molecular target information


    Molecular name:Timp3, tissue inhibitor of metalloproteinase 3


    Aliases:

    • Timp-3


    Gene sequence:NCBI_Gene: 21859

    Protein sequence:


    Mouse Timp3 target molecular function (prediction)


    Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of metalloendopeptidase activity. Acts upstream of or within cellular response to organic substance. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby's fundus dystrophy and dilated cardiomyopathy. Human Ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).


    Rat Timp3 molecular target information


    Molecular name: Timp3, TIMP metallopeptidase inhibitor 3

    Alias:

    • metalloproteinase inhibitor 3
    • TIMP-3
    • tissue inhibitor of metalloproteinase 3
    • tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    • tissue inhibitor of metalloproteinases 3

    Gene sequence:NCBI_Gene: 25358

    Protein sequence:


    Rat Timp3 target molecular function (prediction)


    Predicted to enable metalloendopeptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of proteolysis; response to estrogen; and response to folic acid. Located in cytoplasm. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).