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Overview of IL13 molecular targets

Interleukin 13 (IL-13) is located on chromosome 5q31 and has 30% homology and a similar structure to IL-4. IL-13 is secreted by many cell types, especially type 2 helper T cells (Th2). Similar to the closely related IL-4, IL-13 also has multiple functions on immune cells. Although IL-13 is primarily associated with the induction of airway disease, it also has anti-inflammatory properties. IL-13 can induce changes in hematopoietic cells, but these effects may be less important than those of IL-4. IL-13 specifically induces physiological changes in parasitic infected organs. It also induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell proliferation, and mucus hypersecretion, which can lead to airway obstruction. In addition, IL-13 inhibits HIV-1 replication in primary culture-derived macrophages and may serve as a candidate cytokine to inhibit HIV infection in monocytes and macrophages in vivo.

Human IL13 molecular target information

Molecular name: IL13, interleukin 13

Alias:

• allergic rhinitis
• ALRH
• BHR1
• Bronchial hyperresponsiveness-1 (bronchial asthma)
• IL-13
• interleukin-13
• MGC116786
• MGC116788
• MGC116789
• P600

Gene sequence:NCBI_Gene: 3596

Protein sequence:UniProtKB: P35225

Human IL13 target molecular function (prediction)

Predicted to enable cytokine activity and interleukin-13 receptor binding activity. Involved in several processes, including negative regulation of complement-dependent cytotoxicity; negative regulation of endothelial cell apoptotic process; and positive regulation of interleukin-10 production. Located in extracellular region. Implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Biomarker of several diseases, including Plasmodium falciparum malaria; autoimmune disease (multiple); cystic fibrosis; lung disease (multiple); and scleroderma (multiple).

Mouse Il13 molecular target information

Molecular name: Il13, interleukin 13

Alias:

• Il-13

Gene sequence:NCBI_Gene: 16163

Protein sequence:

• UniprotKB: P20109

Mouse Il13 target molecular function (prediction)

Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of This gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13).

Rat Il13 molecular target information

Molecular name: Il13, interleukin 13

Alias:

• IL-13
• interleukin-13
• T-cell activation protein P600

Gene sequence:NCBI_Gene: 116553

Protein sequence: UniProtKB: P42203

Rat Il13 target molecular function (prediction)

Enables interleukin-13 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of cation transmembrane transport. Located in extracellular space. Used to study asthma; extrinsic allergic alveolitis; and lipoid nephrosis. pulmonary fibrosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13).