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Overview of SELE molecular target information


  • Molecular name: SELE, selectin E
  • Gene family: CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
  • Alias: ESEL; adhesion molecule 1


    • Overview of SELE molecular targets


    E-selectin, also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a 115 kDa glycoprotein that is expressed only after activation by inflammatory cytokines (IL-1β or TNF-α) or endotoxin in endothelial cells. Cell surface E-selectin mediates leukocyte attachment to the endothelium, thus playing an important role in local inflammatory responses. The extracellular region of E-selectin includes a calcium-dependent C2-type lectin domain, an epidermal growth factor (EGF) domain, and six repeats of complement regulatory protein-like sequences. Soluble E-selectin (sE-Selectin) is present in the blood of healthy individuals and is probably produced by proteolytic cleavage of the surface-expressed molecule. Monitoring sE-Selectin levels in serum can provide more detailed insights into several pathological conditions such as cancer, infectious diseases, diabetes, and sepsis.


    Human SELE molecular target information


    Molecule name: SELE, selectin E


    Alias:

    • CD62 antigen-like family member E
    • CD62E
    • E-selectin
    • ELAM
    • ELAM-1
    • ELAM1
    • endothelial adhesion molecule 1
    • endothelial leukocyte adhesion molecule 1
    • ESEL
    • LECAM2
    • leukocyte endothelial cell adhesion molecule 2
    • leukocyte-endothelial cell adhesion molecule 2

    Gene sequence:NCBI_Gene: 6401

    Protein sequence:UniProtKB: P16581


    Human SELE target molecular function (prediction)


    Is integral component of plasma membrane. Implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Biomarker of COVID-19; rheumatic myocarditis; and type 1 diabetes mellitus.


    Mouse Sele molecular target information


    Molecule name: Sele, selectin, endothelial cell


    Alias:

    • CD62E
    • E-selectin
    • Elam
    • endothelial adhesion molecule


    Gene sequence:NCBI_Gene: 20339

    Protein sequence:


    Mouse Sele target molecular function (prediction)


    Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within positive regulation of leukocyte migration. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Orthologous to human SELE (selectin E).


    Rat Sele molecular target information


    Molecule name: Sele, selectin E

    Alias:

    • CD62 antigen-like family member E
    • E-selectin
    • ELAM-1
    • endothelial leukocyte adhesion molecule 1
    • LECAM2
    • leukocyte-endothelial cell adhesion molecule 2
    • selectin, endothelial cell

    Gene sequence:NCBI_Gene: 25544

    Protein sequence:


    Rat Sele target molecular function (prediction)


    Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in inflammatory response; leukocyte migration; and response to cytokine. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E).