NOTCH1 Molecular Target Information Overview
NOTCH1 molecular target review
The Notch signaling pathway is a ubiquitous pathway that controls developmental processes. The Notch family consists of a group of highly conserved proteins that are both cell surface receptors and direct regulators of gene transcription. It plays an important regulatory role in cell proliferation, apoptosis, differentiation, and a series of physiological and pathological processes, and plays a vital role in the occurrence and development of cancer. Notch-1 is a 300kDa type 1 transmembrane glycoprotein and one of the four Notch homologs involved in developmental processes. Members of this type 1 transmembrane protein family share common structural features, including an extracellular domain composed of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of multiple different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate determination. The Notch-1 pathway is associated with cell differentiation, proliferation, apoptosis, and adhesion. Abnormal activation of the Notch-1 signaling pathway has been shown to be associated with the occurrence and development of cancer.
Human NOTCH1 Molecular Target Information
Molecular name: NOTCH1, notch receptor 1
Alias:
- AOS5
- AOVD1
- hN1
- neurogenic locus notch homolog protein 1
- notch 1
- notch gene homolog 1, (drosophila)
- Notch homolog 1, translocation-associated
- TAN1
- translocation-associated notch protein TAN-1
Gene sequence:NCBI_Gene: 4851
Protein sequence:UniProtKB: P46531
Human NOTCH1 target molecular function (prediction)
Enables identical protein binding activity. Involved in several processes, including heart development; negative regulation of endothelial cell migration; and positive regulation of intracellular signal transduction. Part of MAML1-RBP-Jkappa- ICN1 complex and receptor complex. Implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Biomarker of cholangiocarcinoma and endometrial cancer.
Mouse Notch1 molecular target information
Molecule name: Notch1, notch 1
Alias:
- 9930111A19Rik
- lin-12
- Mis6
- Motch A
- N1
- RIKEN cDNA 9930111A19 gene
- Tan1
- translocation-associated Notch
Gene sequence:NCBI_Gene: 18128
Protein sequence:
Mouse Notch1 target molecular function (prediction)
Acts upstream of or within several processes, including animal organ development; nervous regulation system development; and tube morphogenesis. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).
Rat Notch1 molecular target information
Molecular name: Notch1, notch receptor 1
Alias:
- Drosophila Notch homolog 1
- Drosophila Notch homolog 1 (controlling the ectodermal and neural cell fate in Drosophila)
- neurogenic locus notch homolog protein 1
- NOTCH
- notch 1
- Notch gene homolog 1
- Notch gene homolog 1 (Drosophila)
- Notch homolog 1, translocation-associated
- Notch homolog 1, translocation-associated (Drosophila)
- TAN1
Gene sequence:NCBI_Gene: 25496
Protein sequence: UniProtKB: Q07008
Rat Notch1 target molecular function (prediction)
Enables transmembrane signaling receptor activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and positive regulation of macromolecule metabolic process. Located in several cellular components, including Golgi apparatus; acrosomal vesicle; and nucleus. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia;