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LGALS1 Molecular Target Information Overview


  • Molecular name: LGALS1, galectin 1
  • Gene family: Receptor ligands; Galectins
  • Alias: GBP
  • Alias: lectin, galactoside-binding, soluble, 1


    • LGALS1 molecular target review


    Galectins are a family of β-galactoside binding proteins involved in regulating cell-cell and cell-matrix interactions. Galectin-1 can be either a monomer or a homodimer and is present in a variety of cells and tissues. In humans, galectin-1 is a protein encoded by the LGALS1 gene. Secreted Galectin-1 has immunosuppressive and anti-inflammatory effects, inhibiting acute and chronic inflammation and autoimmunity. Mouse Galectin-1 has an 88% homology to human aa sequences, 96% to rat aa sequences, and 84% to horse, sheep, cattle, and pig aa sequences. Galectin-1 is highly expressed at the maternal-fetal interface, contributing to fetal immune privilege. Its immunosuppressive properties also appear to allow tumor cells to evade immune detection. While regulating cell growth and proliferation and inducing apoptosis of activated T cells, Galectin-1 can also regulate cytokine secretion or inhibit the production of proinflammatory cytokines.


    Human LGALS1 Molecular Target Information


    Molecular name: LGALS1, galectin 1


    Alias:

    • 14 kDa laminin-binding protein
    • 14 kDa lectin
    • beta-galactoside-binding lectin L-14-I
    • beta-galactoside-binding protein 14kDa
    • DKFZp686E23103
    • gal-1
    • GAL1
    • galaptin
    • galectin-1
    • GBP
    • HBL
    • HLBP14
    • HPL
    • lactose-binding lectin 1
    • lectin, galactoside binding soluble 1
    • lectin, galactoside-binding, soluble, 1
    • putative MAPK-activating protein PM12
    • S-Lac lectin 1

    Gene sequence:NCBI_Gene: 3956

    Protein sequence:UniProtKB: P09382


    Human LGALS1 target molecular function (prediction)


    Enables RNA binding activity. Involved in positive regulation of viral entry into host cell. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix.


    Mouse Lgals1 molecular target information


    Molecular name: Lgals1, lectin, galactose binding, soluble 1


    Alternate names:

    • AA410090
    • beta galactoside binding protein
    • expressed sequence AA410090
    • Gal-1
    • Galbp
    • galectin-1
    • L14
    • lactose binding soluble lectin, 14 kDa
    • Lect14


    Gene sequence:NCBI_Gene: 16852

    Protein sequence:


    Mouse Lgals1 target molecular function (prediction)


    Enables carbohydrate binding activity. Acts upstream of or within T cell costimulation; myoblast differentiation; and plasma cell differentiation. Located in extracellular space. Is expressed in several structures, including embryo mesenchyme; genitourinary system; integumental system; main olfactory bulb; and olfactory system. Orthologous to human LGALS1 (galectin 1).


    Rat Lgals1 molecular target information


    Molecular name: Lgals1, galectin 1

    Alias:

    • 14 kDa lectin
    • beta-galactoside-binding lectin
    • beta-galactoside-binding lectin L-14-I
    • gal-1
    • galaptin
    • galectin-1
    • lactose-binding lectin 1
    • lectin, galactose binding, soluble, 1
    • lectin, galactose-binding, soluble, 1
    • RL 14.5
    • S-Lac lectin 1

    Gene sequence:NCBI_Gene: 56646

    Protein sequence:UniProtKB: P11762


    Rat Lgals1 target molecular function (prediction)


    Enables identical protein binding activity; lactose binding activity; and laminin binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of erythrocyte aggregation; and response to isolation stress. Located in cell surface; cytosol; and nucleus. Biomarker of B-cell lymphoma; extrahepatic cholestasis; and lipoid nephrosis. Orthologous to human LGALS1 (galectin 1).