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TNFRSF9 molecular target information overview


  • Molecular name: TNFRSF9, TNF receptor superfamily member 9
  • Gene family: CD molecules; Tumor necrosis factor receptor superfamily
  • Alias: CD137; 4-1BB
  • Former name: ILA
  • Alias: tumor necrosis factor receptor superfamily, member 9


    • Overview of TNFRSF9 molecular targets


    4-1BB, also known as TNFRSF9 or CD137, is a receptor of the tumor necrosis factor superfamily. The human 4-1BB gene encodes a type I transmembrane protein consisting of 255 amino acids, including a 17-amino acid N-terminal signal peptide, a 169-amino acid extracellular region, a 27-amino acid transmembrane region, and a 42-amino acid extracellular region. Recombinant human soluble 4-1BB is a 167-amino acid polypeptide (17.7 kDa) that includes a cystine-rich TNFR-like 4-1BB extracellular region. 4-1BB is primarily expressed on the surface of various T cells, and is also expressed in B cells, monocytes, and a variety of transformed cell lines. The protein contributes to clonal proliferation, survival, and T cell development. It can also induce the proliferation of peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3-triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of the protein is induced by lymphocyte activation. TRAF adaptor protein can bind to the protein and transduce signals that activate NF-κB. It is also involved in the development of inflammation in high-fat diet-induced metabolic syndrome.


    Human TNFRSF9 Molecular Target Information


    Molecular name: TNFRSF9, TNF receptor superfamily member 9


    Alias:

    • 4-1BB
    • 4-1BB ligand receptor
    • CD137
    • CD137 antigen
    • CDw137
    • FLJ43501
    • homolog of mouse 4-1BB
    • ILA
    • induced by lymphocyte activation (ILA)
    • interleukin-activated receptor, homolog of mouse Ly63
    • MGC2172
    • receptor protein 4-1BB
    • T cell antigen ILA
    • T-cell antigen 4-1BB homolog
    • T-cell antigen ILA
    • tumor necrosis factor receptor superfamily member 9
    • tumor necrosis factor receptor superfamily, member 9

    Gene sequence:NCBI_Gene: 3604

    Protein sequence:UniProtKB: Q07011


    Human TNFRSF9 target molecular function (prediction)


    Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space. Predicted to be active in external side of plasma membrane.


    Mouse Tnfrsf9 molecular target information


    Molecular name:Tnfrsf9, tumor necrosis factor receptor superfamily, member 9


    Alias:

    • 4-1BB
    • A930040I11Rik
    • AA408498
    • AI325004
    • CD antigen 137
    • Cd137
    • CDw137
    • expressed sequence AA408498
    • expressed sequence AI325004
    • ILA
    • Ly63
    • lymphocyte antigen 63
    • RIKEN cDNA A930040I11 gene


    Gene sequence:NCBI_Gene: 21942

    Protein sequence:


    Mouse Tnfrsf9 target molecular function (prediction)


    Enables cytokine binding activity; identical protein binding activity; and signaling receptor activity. Acts upstream of or within negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; and regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Is expressed in renal vasculature. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9).


    Rat Tnfrsf9 molecular target information


    Molecular name: Tnfrsf9, TNF receptor superfamily member 9

    Alias:

    • 4-1BB
    • LOC500590
    • MGC114552
    • similar to T-cell antigen 4-1BB precursor - mouse
    • tumor necrosis factor receptor superfamily, member 9
    • tumor necrosis factor receptor superfamily, member 9

    Gene sequence:NCBI_Gene: 500590

    Protein sequence: UniProtKB: Q4V895


    Rat Tnfrsf9 target molecular function (prediction)


    Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9).