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F9 Molecular Target Information Overview


  • Molecular name: F9, coagulation factor IX
  • Gene family: Gla domain containing
  • Alias: FIX
  • Alias: Factor IX; plasma thromboplastic component; Christmas disease; hemophilia B


    • F9 molecular target review


    Factor IX, also known as FIX and F9, is a serine protease that belongs to the peptidase family S1. F9 is produced as a zymogen, an inactive precursor, and then undergoes a series of processing steps - removal of the signal peptide, glycosylation, and then cleavage by factor XIa or factor VIIa into a two-chain form connected by disulfide bonds. Antithrombin can inhibit F9. In addition, in humans and mice, the expression of F9 increases with age. F9 deficiency causes hemophilia B. Among the more than 100 F9 mutants, some do not cause any symptoms, but many cause significant bleeding disorders. Recombinant F9 can be used to treat hemophilia B, and the commercial products are BeneFIX and Alprolix. Some rare F9 mutations lead to increased coagulation activity, resulting in coagulation diseases such as deep vein thrombosis. Tranexamic acid may reduce the risk of perioperative bleeding in patients with congenital F9 deficiency undergoing surgical procedures.


    Human F9 Molecular Target Information


    Molecular name: F9, coagulation factor IX


    Alias:

    • Christmas factor
    • coagulation factor 9
    • coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
    • F9 p22
    • factor 9
    • factor IX F9
    • FIX
    • FIX F9
    • HEMB
    • MGC129641
    • MGC129642
    • P19
    • plasma thromboplastic component
    • plasma thromboplastin component
    • PTC
    • serine protease
    • THPH8

    Gene sequence:NCBI_Gene: 2158

    Protein sequence: UniProtKB: P00740


    Human F9 target molecular function (prediction)


    Enables calcium ion binding activity and endopeptidase activity. Involved in blood coagulation and zymogen activation. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in X-linked thrombophilia due to factor IX defect;


    Mouse F9 molecular target information


    Molecular name: F9, coagulation factor IX


    Alias:

    • AW111646
    • Cf-9
    • Cf9
    • expressed sequence AW111646


    Gene sequence:NCBI_Gene: 14071

    Protein sequence:


    Mouse F9 target molecular function (prediction)


    Enables peptidase activity. Acts upstream of or within blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo and liver. Used to study hemophilia B. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Orthologous to human F9 (coagulation factor IX).


    Rat F9 molecular target information


    Molecular name: F9, coagulation factor IX

    Alias:

    • christmas factor
    • coagulation factor 9
    • Coagulation factor IX (plasma thromboplastic component Christmas disease hemophilia B)
    • Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)

    Gene sequence:NCBI_Gene: 24946

    Protein sequence:UniProtKB: P16296


    Rat F9 target molecular function (prediction)


    Predicted to enable calcium ion binding activity and endopeptidase activity. Involved in blood coagulation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect;