SELL Molecular Target Information Overview
SELL molecular target review
L-selectin, also known as CD62L, is a cell surface glycoprotein that is constitutively expressed in various leukocytes. It is a cell adhesion molecule present in lymphocytes and preimplantation embryos and is a member of the selectin family of proteins. Studies have reported that soluble L-selectin (sL-Selectin) exists in two forms. sL-Selectin comes from lymphocytes and has a molecular weight of approximately 62kDa. The molecular weight of sL-Selectin from neutrophils is 75-100kDa. High concentrations of sL-Selectin can prevent lymphocytes from binding to the endothelium, suggesting that sL-Selectin may play a role in regulating lymphocyte-endothelial binding in vivo. Monitoring sL-Selectin levels in serum can provide more detailed insights into some pathological conditions such as sepsis and acquired immunodeficiency syndrome (AIDS).
Human SELL Molecular Target Information
Molecule name: SELL, selectin L
Alias:
- CD62 antigen-like family member L
- CD62L
- gp90-MEL
- hLHRc
- L-selectin
- LAM-1
- LAM1
- LECAM1
- Leu-8
- LEU8
- leukocyte adhesion molecule 1
- leukocyte surface antigen Leu-8
- leukocyte-endothelial cell adhesion molecule 1
- LNHR
- LSEL
- Lyam-1
- LYAM1
- lymph node homing receptor
- lymphocyte adhesion molecule 1
- pln homing receptor
- PLNHR
- TQ1
Gene sequence:NCBI_Gene: 6402
Protein sequence: UniProtKB: P14151
Human SELL target molecular function (prediction)
Enables calcium ion binding activity; oligosaccharide binding activity; and protease binding activity. Involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules and leukocyte tethering or rolling. Is integral component of plasma membrane. Implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Biomarker of Alzheimer's disease; IgA glomerulonephritis; and systemic lupus erythematosus.
Mouse Sell Molecular Target Information
Molecule name: Sell, selectin, lymphocyte
Alias:
- AI528707
- CD62L
- expressed sequence AI528707
- L-selectin
- LECAM-1
- Lnhr
- Ly-22
- Ly-m22
- Lyam-1
- Lyam1
- lymph node homing receptor
- lymphocyte adhesion molecule 1
- lymphocyte antigen 22
- lymphocyte antigen m22
Gene sequence:NCBI_Gene: 20343
Protein sequence:
- UniprotKB: P18337
- UniprotKB: A0A0A6YW25
- UniprotKB: B1B506
- UniprotKB: B1B507
- UniprotKB: Q3TA36
- UniprotKB: Q3TCF3
- UniprotKB: Q3TR50
- UniprotKB: Q3TSW6
- UniprotKB: Q3UV83
Mouse Sell Target Molecular Function (Prediction)
Enables cell adhesion molecule binding activity. Acts upstream of or within response to ATP. Located in external side of plasma membrane. Is expressed in brain; brainstem; submandibular gland epithelium; and testis. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L).
Rat Sell molecular target information
Molecule name: Sell, selectin L
Alias:
- A.11
- CD62 antigen-like family member L
- L-selectin
- LAM-1
- LECAM-1
- LECAM1
- leukocyte adhesion molecule 1
- leukocyte-endothelial cell adhesion molecule 1
- ly-22
- lymph node homing receptor
- lymphocyte antigen 22
- lymphocyte surface MEL-14 antigen
- selectin, lymphocyte
Gene sequence:NCBI_Gene: 29259
Protein sequence:
Rat Sell target molecular function (prediction)
Enables glycolipid binding activity. Involved in several processes, including positive regulation of neutrophil chemotaxis; response to fatty acid; and response to hyperoxia. Located in cell surface. Used to study colitis and peripheral vascular disease. Biomarker of abdominal aortic aneurysm; endometriosis; pancreatitis; and toxic shock syndrome. Human ortholog(s) of this gene implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L).