Overview of BDNF molecular target information
Overview of BDNF molecular targets
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors and is related to nerve growth factor. Neurotrophic factors are present in the brain and periphery. BDNF is processed and synthesized in the endoplasmic reticulum and secreted by dense-core vesicles. It is active in the hippocampus, cortex, and basal forebrain regions of the brain, and is also expressed in the retina, motor neurons, kidneys, saliva, and prostate. BDNF acts on certain neurons in the central and peripheral nervous systems, helping the survival of existing neurons and promoting the growth and differentiation of new neurons and synapses. Changes in BDNF may play a role in the onset of schizophrenia and is associated with depression, eczema, epilepsy, Alzheimer's disease, obesity, aging, congenital central hypoventilation syndrome, and cognitive dysfunction after chemotherapy.
Human BDNF molecular target information
Molecular name: BDNF, brain derived neurotrophic factor
Alias:
- abrineurin
- ANON2
- brain-derived neurotrophic factor
- BULN2
- MGC34632
- neurotrophin
Gene sequence:NCBI_Gene: 627
Protein sequence:UniProtKB: P23560
Human BDNF target molecular function (prediction)
Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Involved in nervous system development; positive regulation of nervous system development; and positive regulation of receptor binding activity. Located in mitochondrion and nuclear speck. Implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; (multiple); lung disease (multiple); mental depression (multiple); neurodegenerative disease (multiple); and open-angle glaucoma (multiple).
Mouse Bdnf molecular target information
Molecular name: Bdnf, brain derived neurotrophic factor
Alias:
- None
Gene sequence:NCBI_Gene: 12064
Protein sequence:
Mouse Bdnf target molecular function (prediction)
Predicted to enable growth factor activity; nerve growth factor receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in negative regulation of apoptotic signaling pathway; positive regulation of neuron projection development; and retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission. Acts upstream of or within several processes, including generation of neurons; modulation of chemical synaptic transmission; and sensory organ development. Located in several cellular components, including dendrite; perinuclear region of cytoplasm; and secretory granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).
Rat Bdnf molecular target information
Molecular name: Bdnf, brain-derived neurotrophic factor
Alias:
- Brain derived neurothrophic factor
- brain derived neurotrophic factor
- MGC105254
Gene sequence:NCBI_Gene: 24225
Protein sequence:
Rat Bdnf target molecular function (prediction)
Enables neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to norepinephrine stimulus; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of glucocorticoid receptor signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and synaptic vesicle. Used to study Alzheimer's disease; cystitis; eye disease (multiple); neuropathy (multiple); and status epilepticus. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; hypertensive encephalopathy; middle cerebral artery infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).