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TNFSF15 molecular target information overview


  • Molecular name: TNFSF15, TNF superfamily member 15
  • Gene family: Tumor necrosis factor superfamily
  • Alias: TL1; VEGI; TL1A; VEGI192A; MGC129934; MGC129935
  • Alias:vascular endothelial cell growth inhibitor; TNF superfamily ligand TL1A; TNF ligand-related molecule 1; vascular endothelial growth inhibitor-192A; tumor necrosis factor (ligand) superfamily, member 15


    • Overview of TNFSF15 molecular targets


    Tumor necrosis factor–like ligand 1A (TL1A), also known as TNFSF15, is a member of the TNF superfamily. It is a 251 amino acid homotrimeric cytokine expressed by the TNFSF15 gene located at 9q32 on chromosome 9. The expression of this protein is induced by TNF and IL-1α and it is abundantly expressed in endothelial cells but not in B or T cells. This cytokine is a ligand for the TNFRSF25 receptor and the TNFRSF21/DR6 decoy receptor. It activates NF-kappaB and MAP kinase and also acts as an autocrine factor to induce apoptosis of endothelial cells. This cytokine also inhibits the proliferation of endothelial cells and therefore may act as an angiogenesis inhibitor.


    Human TNFSF15 molecular target information


    Molecular name: TNFSF15, TNF superfamily member 15


    Alias:

    • MGC129934
    • MGC129935
    • TL1
    • TL1A
    • TNF ligand-related molecule 1
    • TNF superfamily ligand TL1A
    • TNLG1B
    • tumor necrosis factor (ligand) superfamily member 15
    • tumor necrosis factor (ligand) superfamily, member 15
    • tumor necrosis factor ligand 1B
    • tumor necrosis factor ligand superfamily member 15
    • tumor necrosis factor superfamily member 15
    • vascular endothelial cell growth inhibitor
    • vascular endothelial growth inhibitor-192A
    • VEGI
    • VEGI192A

    Gene sequence:NCBI_Gene: 9966

    Protein sequence:UniProtKB: O95150


    Human TNFSF15 target molecular function (prediction)


    Predicted to enable signaling receptor binding activity. Acts upstream of or within activation of NF-kappaB-inducing kinase activity and activation of cysteine-type endopeptidase activity involved in apoptotic process. Located in plasma membrane.


    Mouse Tnfsf15 molecular target information


    Molecular name:Tnfsf15, tumor necrosis factor (ligand) superfamily, member 15


    Alias:

    • TL1
    • TL1A
    • VEGI


    Gene sequence:NCBI_Gene: 326623

    Protein sequence:


    Mouse Tnfsf15 target molecular function (prediction)


    Predicted to enable death receptor binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of cytokine production. Predicted to act upstream of or within activation of NF-kappaB-inducing kinase activity. Predicted to be located in plasma membrane. Used to study inflammatory bowel disease 16. Orthologous to human TNFSF15 (TNF superfamily member 15).


    Rat Tnfsf15 molecular target information


    Molecular name: Tnfsf15, TNF superfamily member 15

    Synonyms:

    • TNF ligand-related molecule 1
    • Tnlg1b
    • tumor necrosis factor (ligand) superfamily, member 15
    • tumor necrosis factor ligand 1b
    • tumor necrosis factor ligand superfamily member 15
    • tumor necrosis factor superfamily member 15
    • vascular endothelial cell growth inhibitor

    Gene sequence:NCBI_Gene: 252878

    Protein sequence:


    Rat Tnfsf15 target molecular function (prediction)


    Enables death receptor binding activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of cytokine production. Predicted to be located in plasma membrane. Orthologous to human TNFSF15 (TNF superfamily member 15).