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CD14 molecular target information overview


  • Molecular name: CD14, CD14 molecule
  • Gene family: CD molecules; Scavenger receptors
  • Alias: CD14 antigen


    • CD14 molecular target review


    CD14 is a glycoprotein expressed on the surface of monocytes, interfollicular macrophages and dendritic cell subsets. CD14 forms a receptor complex with MD-2 (LY) and TLR4, which can specifically respond to LPS and transmit signals. The CD14/MD-2/TLR4 receptor complex transmits signals through MyD88, TIRAP and TRAF6, and finally activates NF-κB.


    Human CD14 Molecular Target Information


    Molecular name: CD14, CD14 molecule


    Alias:

    • cd14 antigen
    • monocyte differentiation antigen CD14
    • myeloid cell-specific leucine-rich glycoprotein

    Gene sequence:NCBI_Gene: 929

    Protein sequence: UniProtKB: P08571


    Human CD14 target molecule function (prediction)


    Acts upstream of or within cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; and positive regulation of tumor necrosis factor production. Located in Golgi apparatus and membrane raft. Is anchored component of external side of plasma membrane. Part of lipopolysaccharide receptor complex. Implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Biomarker of several diseases, including biliary atresia; cystic fibrosis; lung disease (multiple); perinatal necrotizing enterocolitis; and polycystic kidney disease (multiple).


    Mouse Cd14 molecular target information


    Molecular name: Cd14, CD14 antigen


    Alias:

    • None


    Gene sequence:NCBI_Gene: 12475

    Protein sequence:


    Mouse Mouse Cd14 Target Molecular Function (Prediction)


    Predicted to enable lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and toll-like receptor 4 signaling pathway. Located in external side of plasma membrane and membrane raft. Is expressed in several structures, including femur; gallbladder; intestine; reproductive system; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and perinatal necrotizing enterocolitis. Orthologous to human CD14 (CD14 molecule).


    Rat Cd14 molecular target information


    Molecular name: Cd14, CD14 molecule

    Alias:

    • CD14 antigen
    • monocyte differentiation antigen CD14
    • myeloid cell-specific leucine-rich glycoprotein

    Gene sequence:NCBI_Gene: 60350

    Protein sequence:UniProtKB: Q63691


    Rat Cd14 target molecular function (prediction)


    Predicted to enable lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to magnesium ion; and response to tumor necrosis factor. Located in cell surface; extracellular space; and plasma membrane. Used to study perinatal necrotizing enterocolitis. Biomarker of Hirschsprung's disease; cholestasis; obstructive jaundice; and periodontitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Orthologous to human CD14 (CD14 molecule).