EPOR molecular target information overview
Overview of EPOR molecular targets
Erythropoietin receptor (EPOR) is encoded by the EPOR gene in humans. It is a 59 kDa polypeptide and a member of the cytokine receptor family. The cytoplasmic domain of EPOR contains many tyrosines phosphorylated by Janus kinase 2, which serve as anchoring sites for intracellular pathway signaling and transcriptional activators. Loss of the erythropoietin receptor causes erythroleukemia and familial polycythemia. Excessive production of erythrocytes can lead to adverse cardiovascular events such as thrombosis and stroke. EPOR signaling prevents neuronal death and ischemic injury.
Human EPOR molecular target information
Molecular name: EPOR, erythropoietin receptor
Alias:
- EPO-R
- MGC138358
- truncated erythropoietin receptor
Gene sequence:NCBI_Gene: 2057
Protein sequence:UniProtKB: P19235
Human EPOR target molecular function (prediction)
Biomarker of Alzheimer's disease; breast cancer; hypertension; and polycythemia vera.
Mouse Epor molecular target information
Molecular name: Epor, erythropoietin receptor
Alias:
- None
Gene sequence:NCBI_Gene: 13857
Protein sequence:
Mouse Epor target molecular function (prediction)
Predicted to enable erythropoietin receptor activity and identical protein binding activity. Acts upstream of or within animal organ development and signal transduction. Predicted to be located in cytoplasm; external side of plasma membrane; and nuclear speck. Is expressed in several structures, including brain; egg cylinder; genitourinary system; germ layer; 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor).
Rat Epor molecular target information
Molecular name: Epor, erythropoietin receptor
Alias:
- EPO-R
- MGC108723
Gene sequence:NCBI_Gene: 24336
Protein sequence:
Rat Epor target molecular function (prediction)
Enables erythropoietin receptor activity. Involved in several processes, including cellular response to kainic acid; negative regulation of cell death; and negative regulation of nitric oxide biosynthetic process. Located in cytoplasm and external side of plasma membrane. Used to study high grade glioma. Biomarker of several diseases, including brain ischemia; cholangiocarcinoma; end stage renal disease; eye disease (multiple); and hepatic encephalopathy. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor).