MME molecular target information overview
Overview of MME molecular targets
CD10 is a 100 kDa type II transmembrane protein. The CD10 antigen is also known as common acute lymphoblastic leukemia antigen (CALLA), neutral endopeptidase (NEP), gp100, and enkephalinase. Normally, it is expressed on the surface of early B and T lymphoid precursors, neutrophils, and various epithelial cells. CD10 is also expressed in lymphoma cells such as acute lymphoblasts and follicular germinal center lymphoma. CD10 is an endopeptidase that participates in the development of B cells and is also a mediator of neutrophil inflammatory responses.
Human MME molecular target information
Molecular name:MME, membrane metalloendopeptidase
Alias:
- atriopeptidase
- CALLA
- CD10
- CMT2T
- common acute lymphocytic leukemia antigen
- DKFZp686O16152
- enkephalinase
- membrane metallo endopeptidase
- membrane metallo-endopeptidase
- membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
- membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)
- membrane metallo-endopeptidase variant 1
- membrane metallo-endopeptidase variant 2
- MGC126681
- MGC126707
- NEP
- neprilysin
- neprilysin-390
- neprilysin-411
- neutral endopeptidase 24.11
- SCA43
- SFE
- skin fibroblast elastase
Gene sequence:NCBI_Gene: 4311
Protein sequence: UniProtKB: P08473
Human MME target molecular function (prediction)
Enables several functions, including peptidase activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; cellular response to UV; and neuropeptide processing. Located in several cellular components, including brush border; early endosome; and trans-Golgi network. Implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Biomarker of cerebral amyloid angiopathy and periodontitis.
Mouse Pdcd10 molecular target information
Molecule name: Pdcd10, programmed cell death 10
Alternate names:
- 2410003B13Rik
- CCM3
- RIKEN cDNA 2410003B13 gene
- TF-1 cell apoptosis related protein-15
- Tfa15
Gene sequence:NCBI_Gene: 56426
Protein sequence:
Mouse Pdcd10 target molecular function (prediction)
Predicted to enable protein N-terminus binding activity; protein homodimerization activity; and protein kinase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytosol. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in Golgi apparatus. Is expressed in several structures, including cardiovascular system; central nervous system; gut; retina layer; and umbilical artery. cavernous malformation 3. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10).
Rat Pdcd10 molecular target information
Molecule name: Pdcd10, programmed cell death 10
Alias:
- MGC72992
- programmed cell death protein 10
- similar to programmed cell death 10
Gene sequence:NCBI_Gene: 494345
Protein sequence: UniProtKB: Q6NX65
Rat Pdcd10 target molecular function (prediction)
Predicted to enable protein N-terminus binding activity; protein homodimerization activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of cell migration. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10).