Blog

Overview of TNF molecular targets

TNF-α is a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells, and CD4+T cells. It has multiple regulatory functions in immune responses and can also serve as a potential pyrogen. After responding to stimuli (infectious agents or tissue damage), TNF-α circulates throughout the body, activates neutrophils, changes the properties of vascular endothelial cells, regulates the metabolic activity of other tissues, and exhibits tumor-killing activity by inducing local coagulation. TNF-α plays an important role in the pathogenesis of inflammation in joint tissues and other tissues.

Human TNF molecular target information

Molecular name: TNF, tumor necrosis factor

Alias:

• APC1 protein
• cachectin
• DIF
• TNF superfamily, member 2
• TNF-a
• TNF-alpha
• TNF, macrophage-derived
• TNF, monocyte-derived
• TNFA
• TNFSF2
• TNLG1F
• tumor necrosis factor alpha
• tumor necrosis factor ligand 1F
• tumor necrosis factor ligand superfamily member 2
• tumor necrosis factor-alpha

Gene sequence:NCBI_Gene: 7124

Protein sequence:UniProtKB: P01375

Human TNF target molecular function (prediction)

Acts upstream of or within several processes, including regulation of cellular protein metabolic process; regulation of gene expression; and regulation of signal transduction. Located in cell surface; extracellular space; and membrane raft. Is integral component of plasma membrane. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Biomarker of several diseases, including anemia (multiple); autoimmune disease (multiple); eye disease (multiple); kidney disease (multiple); and lung disease (multiple).

Mouse Tnf molecular target information

Molecular name: Tnf, tumor necrosis factor

Alias:

• DIF
• TNF alpha
• TNF-alpha
• Tnfa
• TNFalpha
• Tnfsf1a
• tumor necrosis factor-alpha
• tumor necrosis factor, alpha

Gene sequence:NCBI_Gene: 21926

Protein sequence:

• UniprotKB: P06804
• UniprotKB: A0A0R4J210
• UniprotKB: A0A0U5J4W4
• UniprotKB: Q3U4I6
• UniprotKB: Q3U593
• UniprotKB: Q6TDG3

Mouse Tnf target molecular function (prediction)

Acts upstream of or within several processes, including apoptotic signaling pathway; positive regulation of intracellular signal transduction; and regulation of gene expression. Located in several cellular components, including external side of plasma membrane; phagocytic cup; and recycling endosome. Is Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).

Rat Tnf molecular target information

Molecular name: Tnf, tumor necrosis factor

Alias:

• cachectin
• LOC103694380
• MGC124630
• RATNF
• TNF-a
• TNF-alpha
• Tnfa
• tumor necrosis factor (TNF superfamily, member 2)
• tumor necrosis factor alpha
• tumor necrosis factor ligand superfamily member 2
• tumor necrosis factor superfamily member 2
• tumor necrosis factor superfamily, member 2
• tumor necrosis factor-alpha
• tumor necrosis factor-like

Gene sequence:NCBI_Gene: 24835

Protein sequence:UniProtKB: P16599

Rat Tnf target molecular function (prediction)

Enables tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of macromolecule metabolic process; and positive regulation of neuron death. Located in several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple); congestive heart failure (multiple); inflammatory bowel disease (multiple); lung disease (multiple); and non-alcoholic fatty liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); Orthologous to human TNF (tumor necrosis factor).