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CD38 molecular target information overview


  • Molecular name: CD38, CD38 molecule
  • Gene family: CD molecules
  • Alias: ADP-ribosyl cyclase 1; NAD(+) nucleosidase; CD38 antigen (p45)


    • CD38 molecular target review


    CD38 is a membrane-localized glycoprotein that catalyzes the synthesis and degradation of cyclic adenosine diphosphate ribose and participates in cell adhesion and signal transduction. CD31 is the ligand of CD38. When the two bind, they can cause apoptosis of bone marrow B cells, but can prevent apoptosis of tonsil B cells and promote proliferation of spleen B cells. Normally expressed in thymocytes, early B and T cells, germinal center B cells, some T cells, etc. Abnormally expressed in myeloma cells, primary effusion lymphoma, and some chronic lymphocytic leukemias.


    Human CD38 Molecular Target Information


    Molecular name: CD38, CD38 molecule


    Alias:

    • 2'-phospho-ADP-ribosyl cyclase
    • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
    • 2'-phospho-cyclic-ADP-ribose transferase
    • ADP-ribosyl cyclase 1
    • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
    • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    • ADPRC 1
    • ADPRC1
    • cADPr hydrolase 1
    • cd38 antigen
    • CD38 antigen (p45)
    • cluster of differentiation 38
    • cyclic ADP-ribose hydrolase 1
    • ecto-nicotinamide adenine dinucleotide glycohydrolase
    • NAD(+) nucleosidase
    • T10

    Gene sequence:NCBI_Gene: 952

    Protein sequence:UniProtKB: P28907


    Human CD38 target molecule function (prediction)


    Predicted to enable NAD+ nucleosidase activity and phosphorus-oxygen lyase activity. Involved in several processes, including B cell receptor signaling pathway; positive regulation of B cell proliferation; and regulation of transcription, DNA-templated. Located in plasma membrane. Implicated in type 1 diabetes mellitus and type 2 diabetes mellitus.


    Mouse Cd38 molecular target information


    Molecular name: Cd38, CD38 antigen


    Alias:

    • CD38 antigen, related sequence 1
    • Cd38-rs1


    Gene sequence:NCBI_Gene: 12494

    Protein sequence:


    Mouse Mouse Cd38 Target Molecular Function (Prediction)


    Enables hydrolase activity, acting on glycosyl bonds; identical protein binding activity; and phosphorus-oxygen lyase activity. Acts upstream of or within positive regulation of B cell proliferation. Located in cell surface and membrane. Is expressed in several structures, including alimentary system; genotourinary system; nervous system; respiratory system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule).


    Rat Cd38 molecular target information


    Molecular name: Cd38, CD38 molecule

    Alias:

    • 2'-phospho-ADP-ribosyl cyclase
    • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
    • 2'-phospho-cyclic-ADP-ribose transferase
    • ADP-ribosyl cyclase 1
    • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    • ADPRC 1
    • cADPr hydrolase 1
    • CD38 antigen
    • CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)
    • CD38H
    • cyclic ADP-ribose hydrolase 1

    Gene sequence:NCBI_Gene: 25668

    Protein sequence: UniProtKB: Q64244


    Rat Cd38 target molecular function (prediction)


    Enables NAD+ nucleosidase activity. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane; nucleus; and secretory granule membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule).