Alternative Names
Protein NDRG1; Differentiation-Related Gene 1 Protein; DRG-1; N-myc Downstream-Regulated Gene 1 Protein; Nickel-Specific Induction Protein Cap43; Reducing Agents and Tunicamycin-Responsive Protein; RTP; Rit42; NDRG1; CAP43; DRG1; RTP
Background
Protein NDRG1 is a member of the N-Myc Downregulated Gene family, which is part of the α/β Hydrolase superfamily. Protein NDRG1 is a cytoplasmic protein that is involved in stress responses, hormone responses, cell growth and differentiation. Protein NDRG1 is necessary for p53-mediated caspase activation and apoptosis. Protein NDRG1 mutuations are reported to be the cause for hereditary motor and sensory neuropathy-Lom. Decreased NDRG1 expression in glioma is linked to tumor progression; overexpression of NDRG1 is connected to malignant status of esophageal cancer.
Note
For Research Use Only , Not for Diagnostic Use.