TNF Receptor 2 Rabbit Polyclonal Antibody

TNF Receptor 2 Rabbit Polyclonal Antibody

Size1:50μl Price1:$168
Size2:100μl Price2:$300
Size3:500μl Price3:$1200 SKU: APRab00182 Category: Polyclonal Antibody Tags: , , , , , ,

Datasheet

Summary

Production Name

TNF Receptor 2 Rabbit Polyclonal Antibody

Description

Primary antibody

Host

Rabbit

Application

WB

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification

Affinity Chromatography

 

Immunogen

Gene Name

TNFRSF1B

Alternative Names

CD120b; p75 TNF receptor; p80 TNF alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R75; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII; Tnfrsf1b

Gene ID

7133

SwissProt ID

P20333

 

Application

Dilution Ratio

WB: 1/500-1/1000

Molecular Weight

Calculated MW: 48 kDa; Observed MW: 73 kDa

 

Background

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

 

Research Area

Cell Biology

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