Phospho-IRE1 (Ser724) Rabbit Monoclonal antibody

Phospho-IRE1 (Ser724) Rabbit Monoclonal antibody

Size1:50μL Price1:$188 $99
Size2:100μL Price2:$338 $180
Application:WB
Reactivity:Human
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:ERN1 SKU: AMRe02170 Category: Rabbit Monoclonal Antibody Tags: , , , , ,

Summary

Production Name

Phospho-IRE1 (Ser724) Rabbit Monoclonal antibody

Description

Recombinant Rabbit Monoclonal antibody

Host

Rabbit

Application

WB

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Phosphorylated

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification

Affinity Purified

 

Immunogen

Gene Name

ERN1

Alternative Names

ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a

Gene ID

2081

SwissProt ID

O75460

 

Application

Dilution Ratio

WB: 1:500-1:1000

Molecular Weight

Calculated MW: 110 kDa; Observed MW: 110 kDa

 

Background

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

 

Research Area

Signal Transduction

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