Phospho-4E BP1 (Thr46) Rabbit Monoclonal Antibody

Phospho-4E BP1 (Thr46) Rabbit Monoclonal Antibody

Size1:50μL Price1:$188
Size2:100μL Price2:$338
Size3:200μL Price3:$520
Application:WB,IHC-P,IP
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:EIF4EBP1 SKU: AMRe04050 Category: Rabbit Monoclonal Antibody Tags: , , , , , , , ,

Summary

Production Name

Phospho-4E BP1 (Thr46) Rabbit Monoclonal Antibody

Description

Rabbit Monoclonal antibody

Host

Rabbit

Application

WB,IHC-P,IP

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Phosphorylated

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification

Affinity Purification

 

Immunogen

Gene Name

EIF4EBP1

Alternative Names

EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

Gene ID

1978

SwissProt ID

Q13541

 

Application

Dilution Ratio

WB: 1:500-1:1000 IHC: 1:50-1:100 IP: 1:20

Molecular Weight

Calculated MW: 13 kDa; Observed MW: 15-20 kDa

 

Background

Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.

 

Research Area

Epigenetics and Nuclear Signaling

Related products