HINT1 Mouse Monoclonal Antibody

HINT1 Mouse Monoclonal Antibody

Size1:50μL Price1:$168
Size2:100μL Price2:$300
Application:WB,IHC,ICC,FC
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:HINT1 SKU: AMM85988 Category: Mouse Monoclonal Antibody Tags: , , , , , , , , ,

Summary

Production Name

HINT1 Mouse Monoclonal Antibody

Description

Mouse Monoclonal Antibody

Host

Mouse

Application

WB,IHC,ICC,FC

Reactivity

Human, Mouse, Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

Mouse IgG1

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

Purification

Affinity Purification

 

Immunogen

Gene Name

HINT1

Alternative Names

Histidine triad nucleotide-binding protein 1, 3---, Adenosine 5'-monophosphoramidase, Protein kinase C inhibitor 1, Protein kinase C-interacting protein 1, PKCI-1, HINT1, HINT, PKCI1, PRKCNH1

Gene ID

3094

SwissProt ID

P49773

 

Application

Dilution Ratio

WB:1:4000,IHC:1:100-1:500,ICC:1:25,FC:1:25

Molecular Weight

13.8kDa

 

Background

Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin- protein ligase complex.

 

Research Area

Focal adhesion;ECM-receptor interaction;

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