Parkinson's Disease (PD)

Parkinson's disease (PD) is a common, chronic progressive degenerative disease of the nervous system, which mainly affects motor function and mostly occurs in middle-aged and elderly people. PD is characterized by the gradual degeneration of neurons in specific regions of the brain, namely the significant loss of dopaminergic neurons in the substantia nigra of the midbrain and the formation of intracellular Lewy bodies[1].

In PD patients, dopaminergic neurons of SNpc can die progressively (more than 50% to 70% may be lost over the course of the disease), resulting in a significant decrease in striatal dopamine levels, disrupting the balance of the basal ganglia loop (eg, relatively enhanced function of the inhibitory transmitter γ-aminobutyric acid (GABA)), and ultimately triggering motor symptoms (tremor, myotonia, bradykinesia, etc.)[2].

Normal α - Synuclein (α-synuclein, α-syn) is a soluble small molecule protein mainly distributed in the presynaptic membrane and involved in synaptic vesicle release and synaptic maintenance; In PD, α-syn misfolds (forming β-fold structures) and aggregate into insoluble fibers that eventually form Lewy bodies or neurites. They not only directly damage neuronal structures (such as disrupting synaptic function), but also induce cell death through various pathways (such as inhibiting proteasome activity, interfering with mitochondrial function, activating inflammatory responses, etc.)[3].

Parkinson's pathogenesis

Parkinson-related antibodies

ELISA kits

References

1. Mark J R, Tansey M G. Immune cell metabolic dysfunction in Parkinson’s disease[J]. Molecular Neurodegeneration, 2025, 20(1).

2. Dickson D W. Parkinson's Disease and Parkinsonism: Neuropathology[J]. Cold Spring Harbor Perspectives in Medicine, 2012, 2(8): a009258-a009258.

3. Irmady K, Przedborski S. Progression in Parkinson's Disease[J]. Cold Spring Harbor Perspectives in Medicine, 2025.

Flora Flora is a technical support expert at EnkiLife, familiar with immunology and neuroscience, dedicated to providing customers with high-quality product combinations and technical support to help achieve research in neurodegenerative diseases and other neuroscience areas.

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