Epidermal Growth Factors (EGFs)
Several diseases are associated to disruption of growth factor homeostasis. This is so for the family of epidermal growth factors (EGF) whose altered expression has been linked to several pathogeneses, such as lung adenocarcinoma and several other cancer types, chronic pain, chronic kidney disease and psoriasis. Signaling by EGF growth factors is mediated by the ErbB family of G protein-coupled receptors, which comprises four members (ErbB1 to ErbB4). Binding of the EGF growth factors to the receptors is mediated by the EGF domain, leading to homo or heteroligomerization of the receptors and activating cross-phosphorylation of their intracellular C-terminal domain. Receptor activation may trigger signal transduction to several pathways involved in differentiation, proliferation, migration or survival, with a wide range of targets including PLCϒ, STAT5, SHIP1, Abl, PTP-2c, STAT1, Syk, Vav2, RasA1, SH3BGRL, Grb2, Src, Crk, Nck, Shc and Cb1.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| proHB-EGF (C-6His) | PHH0786 | Recombinant Human proHB-EGF (C-6His) | Human | 15.1 KDa |
| EGF (C-6His) | PEM0557 | Recombinant Mouse EGF (C-6His) | Mouse | 7.2 KDa |
| BTC (N-6His) | PEM0148 | Recombinant Mouse BTC (N-6His) | Mouse | 12.2 KDa |
| NRG1Beta (71AA) | PEH1377 | Recombinant Human NRG1Beta (71AA) | Human | 8.2 KDa |
| NRG1Beta (65AA) | PEH1376 | Recombinant Human NRG1Beta (65AA) | Human | 7.5 KDa |
| NRG1Beta (245AA) | PEH1241 | Recombinant Human NRG1Beta (245AA) | Human | 26.9 KDa |
| EGF | PEH0556 | Recombinant Human EGF | Human | 6.2 KDa |
Validation Data
Recombinant Mouse EGF (C-6His) (Catalog: PEM0557) Recombinant Human NRG1Beta (71AA) (Catalog: PEH1377)
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. 1.EGFs and ERBBs--brief history and prospects. Stern DF. Semin Cell Dev Biol. 2010. [PMID: 20970513]
2. A toolkit for recombinant production of seven human EGF family growth factors in active conformation. Ferreira AS, et al. Sci Rep. 2022. [PMID: 35322149]
3. Eicosanoids and HB-EGF/EGFR in cancer. Yang CC, et al. Cancer Metastasis Rev. 2018. [PMID: 29936588]
4. Epidermal growth factor on the healing of human subacute tympanic membrane perforation. Liu Y. Am J Otolaryngol. 2020. [PMID: 31948693]
5. The ErbB/HER family of protein-tyrosine kinases and cancer. Roskoski R Jr. Pharmacol Res. 2014. [PMID: 24269963]
6. Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis. Holowka D, et al. Biochim Biophys Acta Biomembr. 2017. [PMID: 28024796]
