Tumor Necrosis Factor Superfamily (TNFSF）
The tumor necrosis factor superfamily (TNFSF) is a group of proteins that play a wide and important role in biology. Currently, 19 ligands have been identified in this family, such as TNF-α, TNF-β, CD40L, FasL, TRAIL, RANKL, etc., and 29 receptors correspond to them. TNFSF members are all type II transmembrane proteins, and their C - terminal contains a TNF - homologous domain, which can promote the formation of trimeric complexes of ligands and receptors, thus activating the intracellular signaling pathway. These ligands regulate a variety of cellular functions by binding to different receptors, including immune response, inflammatory response, cell proliferation, differentiation, apoptosis and embryogenesis, etc., playing a key role in maintaining body homeostasis and responding to external stimuli. For example, TNF - α is abnormally expressed in a variety of tumors, which can promote tumor growth, angiogenesis, invasion and metastasis, and at the same time inhibit apoptosis, while TRAIL can selectively induce tumor cell apoptosis and become a new target for tumor treatment. In addition, the over - expression of CD40L is related to a variety of autoimmune diseases, such as lupus erythematosus and rheumatoid arthritis, and the abnormal RANKL/RANK signal is related to osteoporosis.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| TNF alpha | PEV1680 | Recombinant Rabbit TNF alpha | Rabbit | 17.59 KDa |
| TNF alpha | PER1678 | Recombinant Rat TNF alpha | Rat | 17.4 KDa |
| TNF alpha | PEM1681 | Recombinant Mouse TNF alpha | Mouse | 16.4 KDa |
| TNF beta | PEH1901 | Recombinant Human TNF beta | Human | 18.8 KDa |
| TNF alpha | PEH1679 | Recombinant Human TNF alpha | Human | 17.5 KDa |
| TNF alpha (N-6His) | PEH1677 | Recombinant Human TNF alpha (N-6His) | Human | 21.8 KDa |
| TNF alpha (C-6His) | PEH1676 | Recombinant Human TNF alpha (C-6His) | Human | 18.5 KDa |
Validation Data
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. Signalling pathways of the TNF superfamily: a double-edged sword. Aggarwal BB. Nat Rev Immunol. 2003. [PMID: 12949498]
2. The TNF-TNF receptor system. Hehlgans T, et al. Biol Chem. 2002. PMID: [12452434]
3. TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways. Rivas MA, et al. Exp Cell Res. 2008. [PMID: 18061162]
4. The role of tumor necrosis factor receptor superfamily in cancer: insights into oncogenesis, progression, and therapeutic strategies. Xu, J. npj Precis. 2025. [PMID: 40770489]