CDT1 (3N6) Rabbit Monoclonal Antibody

CDT1 (3N6) Rabbit Monoclonal Antibody

Cat: AMRe08589
Size1:50μL Price1:$128
Size2:100μL Price2:$230
Size3:200μL Price3:$380
Application:WB,IHC-P,ICC/IF,IP
Reactivity:Human
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:CDT1 Category: Recombinant Monoclonal Antibody Tags:

Summary

Production Name

CDT1 (3N6) Rabbit Monoclonal Antibody

Description

Rabbit Monoclonal Antibody

Host

Rabbit

Application

WB,IHC-P,ICC/IF,IP

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Purification

Affinity purification

 

Immunogen

Gene Name

CDT1

Alternative Names

CDT 1; Chromatin licensing and DNA replication factor 1; Retroviral integration site 2; RIS2;

Gene ID

81620

SwissProt ID

Q9H211

 

Application

Dilution Ratio

WB 1:1000, IHC-P/IF-P 1:100, ICC/IF 1:100, IP 1:20-1:50

Molecular Weight

60kDa

 

Background

Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene. Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre- replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).

 

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