AMPK alpha Rabbit Monoclonal Antibody

Summary

Production Name	AMPK alpha Rabbit Monoclonal Antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,IP
Reactivity	Human

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Purified antibody in TBS with 0.05% sodium azide,0.05%protective protein and 50% glycerol.
Purification	Affinity Purification

Immunogen

Gene Name	AMPK alpha
Alternative Names	PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase
Gene ID	5563
SwissProt ID	P54646

Application

Dilution Ratio	WB 1:500-1:1000,IP 1:10-1:20
Molecular Weight	Calculated MW: 62 kDa; Observed MW: 62 kDa

Background

AMP-activated protein kinase (AMPK) is highly conserved from yeast to plants and animals and plays a key role in the regulation of energy homeostasis. AMPK is a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits, each of which is encoded by two or three distinct genes (α1, 2; β1, 2; γ1, 2, 3). The kinase is activated by an elevated AMP/ATP ratio due to cellular and environmental stress, such as heat shock, hypoxia, and ischemia.

Research Area

Autophagy,Wnt signaling pathway,PI3K-Akt signaling pathway