HP1 alpha (1E8) Mouse Monoclonal Antibody-EnkiLife

HP1 alpha (1E8) Mouse Monoclonal Antibody

SKU: AMM03609 ★ ★ ★ ★ ★

Size1:50μL Price1:$150
Size2:100μL Price2:$280
Size3:200μL Price3:$520
Application:WB,IHC-P
Reactivity:Human,Rat,Mouse
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:CBX5 Category: Mouse Monoclonal Antibody Tags: Epigenetics and Nuclear Signaling, Mouse, Unconjugated, WB, IHC, Human, Rat, Mouse

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Summary

Production Name	HP1 alpha (1E8) Mouse Monoclonal Antibody
Description	Mouse Monoclonal Antibody
Host	Mouse
Application	WB,IHC-P
Reactivity	Human,Rat,Mouse

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG1
Clonality	Monoclonal Antibody
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3.
Purification	Affinity Purification

Immunogen

Gene Name	CBX5
Alternative Names	CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
Gene ID	23468
SwissProt ID	P45973

Application

Dilution Ratio	WB: 1:500-1:1000 IHC: 1:50-1:100
Molecular Weight	Calculated MW: 22 kDa; Observed MW: 22 kDa

Background

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.