VTN molecular target information overview
Overview of VTN molecular targets
Vitronectin (VTN), a member of the chymosin family, is abundant in serum, extracellular matrix, and bone. It is a secreted protein that exists in single-chain form or in a clamp-shaped, double-chain form formed by disulfide bonds. VTN contains three domains: the N-terminal somatomedin B domain, the central domain with homology to heme, and the C-terminal domain. VTN can promote cell adhesion and spreading, inhibit the membrane destruction of the terminal cell complement pathway, and bind to a variety of serine protease inhibitors. It is speculated to be related to hemostasis, cell migration, and malignant tumors.
Human VTN Molecular Target Information
Molecular name: VTN, vitronectin
Alias:
- complement S-protein
- epibolin
- S-protein
- serum spreading factor
- serum-spreading factor
- somatomedin B
- V75
- vitronectin (serum spreading factor, somatomedin B, complement S-protein)
- VN
- VNT
Gene sequence:NCBI_Gene: 7448
Protein sequence: UniProtKB: P04004
Human VTN target molecular function (prediction)
Enables integrin binding activity. Involved in several processes, including endodermal cell differentiation; regulation of cellular protein metabolism process; and smooth muscle cell-matrix adhesion. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis;
Mouse Vtn molecular target information
Molecule name: Vtn, vitronectin
Alias:
- AI256434
- expressed sequence AI256434
- Vn
Gene sequence:NCBI_Gene: 22370
Protein sequence:
Mouse Vtn target molecular function (prediction)
Enables extracellular matrix binding activity. Involved in oligodendrocyte differentiation. Acts upstream of or within cell-matrix adhesion; extracellular matrix organization; and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and retina. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin).
Rat Vtn molecular target information
Molecule name: Vtn, vitronectin
Alias:
- Aa1018
- MGC124961
- Vn
Gene sequence:NCBI_Gene: 29169
Protein sequence:
Rat Vtn target molecular function (prediction)
Enables collagen binding activity; heparin binding activity; and identical protein binding activity. Involved in liver regeneration and protein polymerization. Located in several cellular components, including Golgi lumen; basement membrane; and rough endoplasmic reticulum lumen. Used to study proteinuria. Biomarker of diabetic retinopathy and visual epilepsy. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin).