TNFSF11 molecular target information overview
Overview of TNFSF11 molecular targets
Tumor necrosis factor-related activation-inducing factor (TRANCE), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11) and nuclear factor κB receptor activator ligand (RANKL), is a member of the TNF superfamily. TRANCE can be expressed by osteoblasts, CD4+ and CD8+ T cells, megakaryocytes, bronchial and intestinal epithelial cells, etc. TRANCE plays a central role in immune response and bone morphogenesis. During bone formation and remodeling, TRANCE expressed by osteoblasts together with M-CSF induces osteoclast formation and activation, leading to bone resorption, and then subsequent bone deposition and remodeling. TRANCE also plays a role in pathological osteoporosis. Inappropriate expression of TRANCE by activated lymphocytes and osteoblasts will lead to excessive absorption and deposition in joints and bones. Excessive TRANCE is associated with many degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis.
Human TNFSF11 Molecular Target Information
Molecular name: TNFSF11, TNF superfamily member 11
Alias:
- CD254
- hRANKL2
- ODF
- OPGL
- OPTB2
- osteoclast differentiation factor
- osteoprotegerin ligand
- RANKL
- receptor activator of nuclear factor kappa B ligand
- receptor activator of nuclear factor kappa-B ligand
- sOdf
- TNF-related activation-induced cytokine
- TNLG6B
- TRANCE
- tumor necrosis factor (ligand) superfamily, member 11
- tumor necrosis factor (ligand) superfamily, member 11
- tumor necrosis factor ligand 6B
- tumor necrosis factor ligand superfamily member 11
- tumor necrosis factor superfamily member 11
Gene sequence:NCBI_Gene: 8600
Protein sequence:UniProtKB: O14788
Human TNFSF11 target molecular function (prediction)
Enables cytokine activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of cell-cell adhesion; and regulation of transcription, DNA-templated. Predicted to be located in extracellular region and plasma membrane. Implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Biomarker of myocardial infarction.
Mouse Tnfsf11 molecular target information
Molecular name:Tnfsf11, tumor necrosis factor (ligand) superfamily, member 11
Alias:
- Ly109l
- ODF
- OPGL
- osteoclast differentiation factor
- RANKL
- TNF-related activation-induced cytokine
- Trance
Gene sequence:NCBI_Gene: 21943
Protein sequence:
Mouse Tnfsf11 target molecular function (prediction)
Acts upstream of or within several processes, including animal organ development; cellular response to stimulus cytokine; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis.
Rat Tnfsf11 molecular target information
Molecular name: Tnfsf11, TNF superfamily member 11
Alias:
- LOC103689974
- ODF
- OPGL
- osteoclast differentiation factor
- osteoprotegerin ligand
- RANKL
- receptor activator of nuclear factor kappa B ligand
- receptor activator of nuclear factor kappa-B ligand
- TNF-related activation-induced cytokine
- TRANCE
- tumor necrosis factor (ligand) superfamily, member 11
- tumor necrosis factor ligand superfamily member 11
- tumor necrosis factor superfamily member 11
Gene sequence:NCBI_Gene: 117516
Protein sequence:
Rat Tnfsf11 target molecular function (prediction)
Predicted to enable cytokine activity; identical protein binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and response to immobilization stress. Predicted to be located in extracellular space and plasma membrane. recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11).