Summary
Performance
Immunogen
Application
Background
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011],function:Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).,similarity:Belongs to the AKAP95 family.,subcellular location:Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis.,subunit:Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis.,tissue specificity:Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.,
Research Area
Epigenetics and Nuclear Signaling
