Aconitase 1 (7U6) Rabbit Monoclonal Antibody-EnkiLife

Aconitase 1 (7U6) Rabbit Monoclonal Antibody

Summary

Production Name	Aconitase 1 (7U6) Rabbit Monoclonal Antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,ICC/IF,FC
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Purification	Affinity purification

Immunogen

Gene Name	ACO1
Alternative Names	ACO 1; Aconitase; Citrate hydro lyase; IREB1; IRP 1; Iron responsive element binding protein 1;
Gene ID	48
SwissProt ID	P21399

Application

Dilution Ratio	WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:50-1:200
Molecular Weight	98kDa

Background

Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1946430, PubMed:1281544, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004).

Research Area

Cardiovascular; Blood; Signal Transduction; Metabolism; Energy Metabolism; Epigenetics and Nuclear Signaling; DNA / RNA; RNA Processing; Vitamins / Minerals; Pathways and Processes; Metabolic signaling pathways; Nucleotide metabolism; Energy transfer pathways; Energy Metabolism;