Summary
Performance
Immunogen
Application
Background
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Research Area
Cardiovascular; Lipids / Lipoproteins; Adipose Related; Acrp; Signal Transduction; Growth Factors/Hormones; Hormones; Neuroscience; Neurology process; Metabolism; Stem Cells; Mesenchymal Stem Cells; Adipogenesis; Atherosclerosis; Diabetes associated; Cancer; Cancer Metabolism; Response to hypoxia; Metabolism; Pathways and Processes; Metabolism processes; Hypoxia;Types of disease; Diabetes; Obesity; Heart disease; Metabolic disorders
