Summary
Performance
Immunogen
Application
Background
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
Research Area
TGF-beta signaling pathway,PI3K-Akt signaling pathway,MAPK signaling pathway
