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Bcl6 Rabbit Polyclonal Antibody($99/20μL)

Bcl6 Rabbit Polyclonal Antibody($99/20μL)

Cat: APRab00377
Size:20μL Price:$99
Size:50μL Price:$150
Size:100μL Price:$280
Size:200μL Price:$520
Application:WB,IHC,ICC/IF,ELISA
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:BCL6 Category: Polyclonal Antibody Tags: , , , , , , , , ,

Summary

Production Name

Bcl6 Rabbit Polyclonal Antibody

Description

Rabbit polyclonal Antibody

Host

Rabbit

Application

WB,IHC,ICC/IF,ELISA

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3.

Purification

Affinity Purification

 

Immunogen

Gene Name

BCL6

Alternative Names

BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

Gene ID

604

SwissProt ID

P41182

 

Application

Dilution Ratio

WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000

Molecular Weight

Calculated MW: 79 kDa; Observed MW: 79 kDa

 

Background

Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NFκB expression, thereby inhibiting NFκB-mediated cellular functions.HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs).

 

Research Area

Epigenetics and Nuclear Signaling

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