CEACAM6 (1P7) Rabbit Monoclonal Antibody

CEACAM6 (1P7) Rabbit Monoclonal Antibody

SKU: AMRe08617 ★ ★ ★ ★ ★
Size1:50μL Price1:$128
Size2:100μL Price2:$230
Size3:200μL Price3:$380
Application:WB,IHC-P,ICC/IF,FC,IP
Reactivity:Human
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:CEACAM6 Category: Recombinant Monoclonal Antibody Tags: , , , , , , , ,

Summary

Production Name

CEACAM6 (1P7) Rabbit Monoclonal Antibody

Description

Rabbit Monoclonal Antibody

Host

Rabbit

Application

WB,IHC-P,ICC/IF,FC,IP

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Purification

Affinity purification

 

Immunogen

Gene Name

CEACAM6

Alternative Names

CD66c; CEACAM6; CEAL; NCA; Non specific cross reacting antigen; Normal cross reacting antigen;

Gene ID

4680

SwissProt ID

P40199

 

Application

Dilution Ratio

WB 1:1000, IHC-P/IF-P 1:200-1:2000, ICC/IF 1:200-1:500, FC 1:200-1:500, IP 1:20-1:50

Molecular Weight

37kDa

 

Background

Mediate homotypic and heterotypic intercellular adhesion events independently of cell type . Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).

 

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