CNOT7 Rabbit Monoclonal Antibody

CNOT7 Rabbit Monoclonal Antibody

Cat: AMRe86524
Size:50μL Price:$168
Size:100μL Price:$300
Application:WB,ICC/IF,FC,IP
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:CNOT7 Category: Recombinant Monoclonal Antibody Tags: , , , , , , , ,

Summary

Production Name

CNOT7 Rabbit Monoclonal Antibody

Description

Recombinant rabbit monoclonal antibody

Host

Rabbit

Application

WB,ICC/IF,FC,IP

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% protective protein. Stable for 12 months from date of receipt.

Purification

Affinity Purification

 

Immunogen

Gene Name

CNOT7

Alternative Names

Caf1; Pop2; CAF-1; AU022737

Gene ID

18983

SwissProt ID

Q60809

 

Application

Dilution Ratio

WB 1:500-1:2000,ICC/IF 1:500-1:1000,FC 1:200-1:1000,IP 1:20-1:50

Molecular Weight

Calculated MW:33 kDa; Observed MW:33 kDa

 

Background

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation.

 

Research Area

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