Name: DOCK8 Rabbit Monoclonal Antibody
Brand: Enkilife Limited
SKU: AMRe85516
Price: 168 USD
Availability: InStock
Rating: 5 (1 reviews)

DOCK8 Rabbit Monoclonal Antibody

Cat: AMRe85516

Size:50μL Price:$168
Size:100μL Price:$300
Application:WB,ICC
Reactivity:Human
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:DOCK8 Category: Recombinant Monoclonal Antibody Tags: Rabbit, Unconjugated, WB, ICC, Human

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Summary

Production Name	DOCK8 Rabbit Monoclonal Antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,ICC
Reactivity	Human

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Purified antibody in TBS with 0.05% sodium azide,0.05%protective protein and 50% glycerol.
Purification	Affinity Purification

Immunogen

Gene Name	DOCK8
Alternative Names	MRD2; ZIR8; HEL-205
Gene ID	81704
SwissProt ID	Q8NF50

Application

Dilution Ratio	WB 1:500-1:1000,ICC 1:50-1:200
Molecular Weight	Calculated MW: 239 kDa; Observed MW: 239 kDa

Background

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC . Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).

Research Area