Summary
| Production Name | KD-Validated Cytoplasmic Fmr1 Interacting Protein 1 Recombinant Rabbit Monoclonal Antibody |
| Description | KD-Validated antibody |
| Host | Rabbit |
| Application | WB,FCM,ICC |
| Reactivity | Human,Mouse,Rat |
Performance
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | Rabbit IgG |
| Clonality | Rabbit mAb |
| Form | Liquid |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Buffer | Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide. |
| Purification | Affinity purification |
Immunogen
| Gene Name | CYFIP1 |
| Alternative Names | CYFIP1; Cytoplasmic FMR1 Interacting Protein 1; P140SRA-1; KIAA; Cytoplasmic FMRP Interacting Protein 1; Cytoplasmic FMR1-Interacting Protein 1; Specifically Rac1-Associated Protein 1; Selective Hybridizing Clone; P140sra-1; SRA-1; Sra-1; SRA1 |
| Gene ID | 23191 |
| SwissProt ID | Q7L576 |
Application
| Dilution Ratio | WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 |
| Molecular Weight | Calculated MW: 145.2kDa |
Background
This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization. This protein also interacts with the synaptic functional regulator FMR1 protein and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, Mar 2022]
Research Area
Cancer