Summary
| Production Name | KD-Validated Histone Deacetylase 8 Recombinant Rabbit Monoclonal Antibody |
| Description | KD-Validated antibody |
| Host | Rabbit |
| Application | WB,FCM,ICC |
| Reactivity | Human |
Performance
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | Rabbit IgG |
| Clonality | Rabbit mAb |
| Form | Liquid |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Buffer | Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide. |
| Purification | Affinity purification |
Immunogen
| Gene Name | HDAC8 |
| Alternative Names | HDAC8; Histone Deacetylase 8; HDACL1; KDAC8; RPD3; Protein Decrotonylase HDAC8; Histone Deacetylase-Like 1; Protein Deacetylase HDAC8; MRXS6; HD8; WTS; Wilson-Turner X-Linked Mental Retardation Syndrome; EC 3.5.1.98; EC 3.5.1.-; CDA07; CDLS5 |
| Gene ID | 55869 |
| SwissProt ID | Q9BY41 |
Application
| Dilution Ratio | WB 1:4,000-1:20,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 |
| Molecular Weight | Calculated MW: 41.8kDa |
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Research Area
Epigenetics and Nuclear Signaling,Stem Cells,Cardiovascular,Neuroscience