KD-Validated NEFL Mouse Monoclonal Antibody

Summary

Production Name	KD-Validated NEFL Mouse Monoclonal Antibody
Description	KD-Validated antibody
Host	Mouse
Application	WB
Reactivity	Human

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	Mouse IgG1
Clonality	Mouse mAb
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
Purification	Affinity purification

Immunogen

Gene Name	NEFL
Alternative Names	NEFL; Neurofilament Light Chain; NF68; NFL; PPP1R110; CMT1F; CMT2E; Protein Phosphatase 1, Regulatory Subunit 110; Neurofilament, Light Polypeptide 68kDa; Neurofilament Light Polypeptide; Neurofilament Triplet L Protein; NF-L; Light Molecular Weight Neurofilament Protein; Neurofilament Protein, Light Chain; Neurofilament, Light Polypeptide; 68 KDa Neurofilament Protein; Neurofilament Subunit NF-L; Neurofilament Light; CMTDIG
Gene ID	4747
SwissProt ID	P07196

Application

Dilution Ratio	WB 1:400-1:2,000
Molecular Weight	Calculated MW: 61.5kDa

Background

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

Research Area

Developmental Biology,Neuroscience,Signal Transduction,Stem Cells