KD-Validated PCNA Mouse Monoclonal Antibody

Summary

Production Name	KD-Validated PCNA Mouse Monoclonal Antibody
Description	KD-Validated antibody
Host	Mouse
Application	WB,FCM,ICC,IHC-P
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	Mouse IgG1
Clonality	Mouse mAb
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
Purification	Affinity purification

Immunogen

Gene Name	PCNA
Alternative Names	PCNA; Proliferating Cell Nuclear Antigen 2; Cyclin; DNA Polymerase Delta Auxiliary Protein; ATLD2
Gene ID	5111
SwissProt ID	P12004

Application

Dilution Ratio	WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200
Molecular Weight	Calculated MW: 28.8kDa

Background

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

Research Area

Cell Biology,Epigenetics and Nuclear Signaling,Tags & Cell Markers

KD-Validated PCNA Mouse Monoclonal Antibody

KD-Validated PCNA Mouse Monoclonal Antibody

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