KD-Validated TANK Binding Kinase 1 Recombinant Rabbit Monoclonal Antibody-EnkiLife

KD-Validated TANK Binding Kinase 1 Recombinant Rabbit Monoclonal Antibody

Summary

Production Name	KD-Validated TANK Binding Kinase 1 Recombinant Rabbit Monoclonal Antibody
Description	KD-Validated antibody
Host	Rabbit
Application	WB,FCM,ICC,IHC-P
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	Rabbit IgG
Clonality	Rabbit mAb
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
Purification	Affinity purification

Immunogen

Gene Name	TBK1
Alternative Names	TBK1; TANK Binding Kinase 1; NAK; Serine/Threonine-Protein Kinase TBK1; NF-Kappa-B-Activating Kinase; TANK-Binding Kinase 1; T2K; NF-KB-Activating Kinase; EC 2.7.11.1; EC 2.7.11; FTDALS4; IIAE8
Gene ID	29110
SwissProt ID	Q9UHD2

Application

Dilution Ratio	WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200
Molecular Weight	Calculated MW: 83.6kDa

Background

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]

Research Area

Signal Transduction,Epigenetics and Nuclear Signaling,Neuroscience