KD-Validated TIA1 Recombinant Rabbit Monoclonal Antibody-EnkiLife

KD-Validated TIA1 Recombinant Rabbit Monoclonal Antibody

Summary

Production Name	KD-Validated TIA1 Recombinant Rabbit Monoclonal Antibody
Description	KD-Validated antibody
Host	Rabbit
Application	WB,FCM,ICC
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	Rabbit IgG
Clonality	Rabbit mAb
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
Purification	Affinity purification

Immunogen

Gene Name	TIA1
Alternative Names	TIA1; TIA1 Cytotoxic Granule Associated RNA Binding Protein; TIA-1; T-Cell-Restricted Intracellular Antigen-1; Cytotoxic Granule Associated RNA Binding Protein TIA1; Nucleolysin TIA-1 Isoform P40; TIA1 Cytotoxic Granule-Associated RNA-Binding Protein; P40-TIA-1 (Containing P15-TIA-1); RNA-Binding Protein TIA-1; P40-TIA-1; ALS26; WDM
Gene ID	7072
SwissProt ID	P31483

Application

Dilution Ratio	WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000
Molecular Weight	Calculated MW: 43.0kDa

Background

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]

Research Area

Cell Biology,Immunology,Epigenetics and Nuclear Signaling,Cancer